The most popular anime...

[the Black Monarch]

Time for yet another B3 longness post ... just kidding, I'll keep this one short.

Best Series (in no particular order):
Cowboy Bebop
Outlaw Star
Inuyasha
Final Fantasy Unlimited
Neon Genesis Evangelion
Escaflowne
Tenchi Muyo (all 3)
Love Hina
Oh! My Goddess
Dragonball Z
Trigun
Record of Lodoss War (both)
Excel Saga
Ronin Warriors

Best Movies (in no particular order)
Oh! My Goddess the Movie
Street Fighter 2 the Animated Movie
Vampire Hunter D
Vampire Hunter D Bloodlust
End of Eva
Ninja Scroll
Fatal Fury the Movie
Z.O.E. Idalo (i think )
Tenchi Muyo (all 3)
Escaflowne the Movie
Ghost in the Shell
Blood the Last Vampire
Slayers the Motion Picture

Those are all just some that I could think of off the top of my head right now...

You put DBZ on that list, automatically disqualifying all of your opinions about everything

[houndofscales]

Akira
Shinseiki Evangelion
Trigun
Hellsing
Cowboy Bebop

Hold on a second there, Wolfwood. I understand what you mean when you say these are popular (LOVE 'EM!), but the question here is about anime you haven't seen. Obviously, your name and avatar indicate that you've seen plenty of Trigun. Not trying to offend or anything, I just wanted to tell you that you may have misunderstood the topic.
... sorta like telling a friend they have broccoli stuck in their teeth...


Anime I haven't seen... Evangaleon... lodoss... umm, lots of other stuff...
hmm, I really need to see some of these...

[escaflowne_moon]

I haven't seen Gundam Seed yet.

[borpii]

I haven't seen Lain.

Do you mean the Lain that they show on Anime Unleashed? That one doesn't appeal to me too much but if you watch anything enough you will probably get into it.
Anyway... tha most popular anime? Around here it sure ain't Dragonball Z, huh?

[borpii]

I went back and read the 1st post again... the most popular anime you haven't seen! My bad!
Evangelion?
Weiss Kruez?

[HellBlazer]